Ziloprim is the name of Allopurinol, which is used to treat gout, high levels of uric acid in the body (often caused by certain types of cancer and cancer treatment), and kidney stones.
The drug can also be used to treat seizures, infections and pain caused by pancreatic disease. It is sometimes used to improve survival after shunting, to prevent rejection of kidney transplants or to reduce recurrences of the ulcer.
Allopurinol is a type of drug called a xanthine oxidase inhibitor. It works by reducing the production of uric acid in the body. It is supplied as a tablet for oral administration.
Your doctor is likely to start with a low dose of Allopurinol and gradually increase it. It may take several months before you feel all the benefits of this medication. Allopurinol may increase the number of gout attacks during the first few months of admission, but eventually it will prevent their occurrence.
You should tell your doctor if you have any of the following conditions before taking Allopurinol:
- Liver disease
- Kidney disease
- Chronic heart failure
- High blood pressure
- Pregnancy or breastfeeding
- You take chemotherapy drugs
Regularly consult a doctor while taking this medication. Your blood needs to be checked to find out the reaction of your body to the medicine.
Some less serious side effects of Allopurinol may include:
- Pain in the muscles
- Changes in taste
Serious side effects
Immediately consult your doctor if you experience the following serious side effects:
- Fever, sore throat and headache
- Any signs of skin rashes, no matter how mild
- Nausea, stomach pain, itching, loss of appetite, weight loss, dark urine, clayey stool, jaundice
- Pain or bleeding when urinating
- Urination less often or not at all
- Pain or flu syndrome
- Light bruises, unusual bleeding, purple or red spots under the skin
- Severe tingling, numbness, pain, or muscle weakness
Because other medications can interact with Allopurinol, tell your doctor about all the medicines that you take, especially:
- Azathioprine (Imuran)
- Chlorpropamide (diabetin)
- Ciclosporin (Gengraf, Sandimmune, Neoral)
- Mercaptopurine (Purinethol)
- Antibiotics such as ampicillin (Principen, Omnipen, others) or amoxicillin (Amoxil, Augmentin, Trimox, Wymox)
- Blood solvents such as warfarin (coumadin)
Should I avoid any food, drink or activity when taking Allopurinol?
Avoid drinking alcohol while taking Allopurinol, since it can worsen your condition. Allopurinol can worsen your thinking or reaction time, so you should be especially careful when driving or doing anything that requires you to be watchful.
Your doctor may advise you to follow a special diet to help you treat your condition.
Dosage of Allopurinol
A typical adult dose of Allopurinolaot gout:
Initial dose: 100 to 200 milligrams (mg), once a day.
Maintenance dose: 200-300 mg orally, once a day, for easy gout or 400 to 600 mg per day in divided doses for moderately severe gout.
You should take each dose of Allopurinol with a full glass of water. To reduce the risk of kidney stones, you should drink eight to ten full glasses of liquid a day.
Allopurinol: an overdose
If you suspect an overdose, call for emergency help or contact a toxicology center.
The missed dose of Allopurinol
If you miss a dose of Allopurinol, take it as soon as you remember. Leave it if it’s time for the next scheduled dose. Do not take an extra dose to make up for the missed one.