Norvasc is the trade name Amlodipine besylate, a prescription drug used to treat hypertension or high blood pressure.
Norvasc is also used to treat coronary artery disease (CAD) in patients without heart failure and some types of angina (chest pain) of CAD, such as angina caused by action and stress (chronic stable angina).
The drug can also reduce the risk of cardiovascular events associated with high blood pressure, such as strokes and heart attacks.
Norvasc belongs to a class of drugs called calcium channel blockers that block the flow of calcium into the heart muscles and muscles along the walls of the blood vessels.
Since the contraction of these muscles depends on calcium, Norvasc relaxes and dilates the blood vessels, thereby improving blood flow.
Manufactured by Pfizer, Norvasc was first approved by the Food and Drug Administration (FDA) in 1987.
Although the study showed little common benefit for patients with severe heart failure, it suggested that Norvasc could prolong the life of a subgroup of people with heart failure from non-ischemic cardiomyopathy (cardiac muscle damage not associated with low coronary artery blood supply).
To explore this possibility, Pfizer sponsored the PRAISE-2 study, which did not find an advantage for the subgroup in the PRAISE-1 study and was presented at the 2000 conference.
However, the results of the study were not published in the academic journal until 2013, which led to the fact that some experts asked whether Pfizer intentionally postpones the publication so that the data is not publicly available.
People with sensitivity to amlodipine should not take Norvask.
Although Norvasc is used to treat angina, worsening of chest pain and heart attacks can develop after the onset or increase in the dose of the drug – this is especially true for people with severe obstructive coronary artery disease.
Norvascus can also cause symptomatic hypotension (low blood pressure), especially in people with a heart valve problem called aortic stenosis.
Before you start taking NORWASKA, tell your doctor if you have ever had heart disease or liver problems, since you may need another course of treatment.
Pregnancy and Norvasc
Norvasc is a possible danger to unborn babies.
Animal studies have shown that Norvasc increases the risk of fetal death in the womb, prolongs the duration of pregnancy and childbirth, but there have not been adequate and controlled studies in pregnant women.
Therefore, the drug should be used only during pregnancy, if the benefits for the mother outweigh the risks for the unborn child.
Women who breastfeed should not use Norvasc, because it is not known whether the drug is excreted in breast milk.
Side effects of Norvasca
The most common side effect of Norvasc is swelling or swelling of the hands, feet, ankles. You are more likely to experience swelling with higher doses of Norvasca. Other common side effects:
- Abdominal pain
- Drowsiness and fatigue
Severe side effects
Taking Norvasca can lead to several serious side effects. Seek immediate medical attention:
- More frequent or severe chest pain
- Palpitations (fast, severe, or irregular)
Rare side effects
In clinical trials, Norvasc has been associated with numerous rare side effects that affect less than one percent of people. These include:
- Muscle spasms
- Diarrhea, vomiting and weight changes
- Abnormal vision
- Depression and anxiety
- Itching and rash
- Labored breathing
If you experience any serious side effects, consult a doctor.
When taking Norvasca, you should not take more than 20 mg (mg) of a drug that reduces cholesterol, simvastatin (Zocor, Vytorin).
Other drugs that can interact with Norvasc include:
- Inhibitors of the liver enzyme CYP3A4, including ketoconazole (Nizoral, Ekstina), itraconazole (Sporanox) and ritonavir (Norvir)
- Sildenafil (Viagra)
- Cyclosporin (Restasis, Neoral)
Although Norvasc is known to not interact with many medications, be sure to tell your doctor about any medications that you are taking.
Norvasc and grapefruit
There is little evidence that grapefruit and grapefruit juice will interact with Norvask. However, to be safe, think about how to avoid all the products of grapefruit, if you also take Norvask.
Dosage of Norvasca
Norvasc is supplied in three sizes of tablets, which should be taken once a day with or without food: 2.5 mg, 5 mg and 10 mg.
Adults usually start with a dose of 5 mg with a maximum dose of 10 mg. Adults who are small, fragile, elderly or have liver problems, can begin with a dose of 2.5 mg.
Children aged 6 to 17 years can be given doses of 2.5 to 5 mg – a daily dose of more than 5 mg has not been studied in children. The influence of Norvasc on children under the age of 6 is unknown.
Overdose can lead to rapid heartbeat and severe hypotension, which can lead to dizziness and fainting.
If you feel an overdose, call a local poison control center or contact the nearest emergency hospital immediately.
If someone who takes Norvascus collapses or does not breathe, call 03.
Missed dose of Norvasca
Take a dose of Norvasc at the same time every day.
If you miss a dose, take it as soon as you remember.
If more than 12 hours have passed since the missed dose, wait and take the next dose at the usual time.