Ampicillin is the generic name of a drug that is prescribed for the treatment of bacterial infections.
It was once sold under several trademarks, such as Omnipen, Amcill and Principen.
Although these brand names are no longer sold on the market, your health care provider can prescribe general ampicillin for the treatment of infections such as pneumonia, bronchitis, urinary tract infections, meningitis, and typhoid fever.
Dentists often prescribe ampicillin before the dental procedure to people who are at risk of endocarditis, an infection in the lining of the heart.
Ampicillin, a penicillin-like preparation, is an antibiotic that belongs to the class of drugs known as aminopenicillins. It kills bacteria, preventing the creation of their protein, necessary for the creation of cell walls.
Ampicillin was approved by the Food and Drug Administration (FDA) under the Ominpen trademark in 1965 and was originally produced by Wyeth Ayerst.
You should not take ampicillin if:
- You are allergic to ampicillin, any penicillin antibiotic or any other ingredient in the drug
- You have infectious mononucleosis
Talk with your doctor before taking ampicillin if you have:
- Allergy to many things
- Asthma or ever had asthma
- Acute lymphoid leukemia (ALL), a type of leukocyte cancer
- HIV AIDS
- Kidney problems
- Inflammation or intestinal infection caused by the recent use of antibiotics
Pregnancy and ampicillin
Ampicillin is an FDA category B pregnant pregnancy, as animal studies indicate that there is no risk to the fetus, but there is no research showing that it is safe for the unborn child.
Tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Ampicillin is safe for mothers during breastfeeding. However, tell your doctor if you are breastfeeding or plan breastfeeding while taking it.
Common side effects include:
- Diarrhea, nausea and vomiting
- Swelling of the tongue
- Black language
- High levels of eosinophils, type of leukocytes
Serious side effects include:
- Anaphylaxis, a life-threatening allergic reaction in which your throat can close, you will have trouble breathing, and your skin will be covered with urticaria
- difficile colitis, a bacterial infection that causes a severe form of loose, watery diarrhea with an unusually unpleasant odor
- A viable skin reaction, called multiform erythema (Stevens-Johnson syndrome)
- Low level of erythrocytes
- The inability of the bone marrow to produce neutrophils, the type of leukocytes
- Superinfection, an infection that occurs simultaneously or after an initial infection
- Low levels of platelets, cells required for blood clotting, or leukocytes
It is always important to share with your doctor and pharmacist all the medicines that you take. Including prescription drugs, over-the-counter drugs, vitamins, nutritional supplements (nutritious cocktails, protein powders, etc.), herbal remedies and any illegal or recreational drugs.
You should not take ampicillin if you are taking Theracrys.
Medications that have serious interactions with ampicillin include the following:
- Vivotif (live typhoid vaccine)
- Warfarin (Jantoven, Kumadin)
- Methotrexate (Trexall, Rasuvo, Otrexup)
- Magnesium citrate (Citroma, magnesia citrate)
- Exenatide (Betta, Bidureon)
- Acid reflux drugs such as Prevacid (deslansoprazole), Prilosec (omeprazole), Nexium (esomeprazole), and Protonix (pantoprazole)
- Tramadol, (Ultram, Ultracet)
- Doxycycline (Vibramycin, Dorix)
- Tiagabine (Gabritrile)
- Bupropion (Wellbutrin, Zyban, Forfivo XL)
- Allopurinol (Ziloprim, Lopurin, Aloprim)
Ampicillin and alcohol
Since there are no known interactions between ampicillin and alcohol, you do not need to avoid or limit alcohol use while taking ampicillin.
Ampicillin and grapefruit
Grapefruit interacts with some antibiotics, but it is unclear whether ampicillin is on their list. Avoid eating grapefruit or drinking grapefruit juice while taking the medication.
Ampicillin is supplied in the form of tablets, syrup and a solution that can be injected intravenously or into the muscles of the thigh and shoulder.
For general bacterial infections, your doctor may prescribe taking 250 mg to 500 mg every six hours for 14 days.
If you stop taking ampicillin before the completion of the entire prescribed amount, the infection may return and may be even more difficult to treat than the first time.
You should always take ampicillin one hour before or two hours after a meal.
If you suspect an overdose, you should immediately contact a toxicology center or an emergency room. You can contact the toxicology department .
Call 911 if someone has collapsed or is not breathing from a possible serious allergic reaction to ampicillin.
The missed dose of ampicillin
If you miss a dose of ampicillin, try to take it as soon as you remember.
If it’s time for the next dose, skip it and take the next dose in regular time. Do not take two doses of the medication at the same time.