Buspirone is a prescription medicine used to treat anxiety.
It belongs to the group of anti-anxiety drugs called anxiolytics, but it seems to work a little differently than other drugs in this class.
Although researchers do not know exactly how Buspirone reduces anxiety, they believe that it competes with serotonin and dopamine, which are neurotransmitters (chemical brain messengers) associated with the onset of anxiety symptoms.
Buspirone is not intended to treat accidental stress associated with everyday life. Rather, doctors prescribe Buspirone for anxiety disorder and short-term relief of anxiety symptoms.
You can be diagnosed with an anxiety disorder if you have at least one full month of anxious symptoms such as tremors, stress, irritability, dizziness, anxiety, fear, upset stomach and sleeping problems.
The Food and Drug Administration (FDA) approved Buspirone in 1986 for the drug manufacturer Bristol-MyersSquibb under the BuSpar brand.
In 2001, the FDA approved a generic version of Buspirone for several drug manufacturers, and Bristol-MyersSquibb ceased using the BuSpar trade name.
Recently, researchers began to explore other possible uses of buspirone.
A study conducted in 2013 in the journal InternationalReviewofNeurobiology showed that Buspirone can be an effective treatment for Tourette’s syndrome, a brain disorder that causes people to make uncontrolled and repetitive movements and sounds (tics).
An earlier study published in 2011 in TherapeuticAdvancesinNeurologicalDisorders also showed that buspirone can reduce the incidence and severity of Tourette’s syndrome.
You should not take Buspirone if you are taking a monoamine oxidase inhibitor (MAOI), the type of drug used to treat depression.
Examples of MAOI include phenelzine (Nardil) and tranylcypromine (Parnate).
Taking Buspirone with MAOI can cause a dangerous increase in blood pressure.
Studies have shown that Buspirone’s safety does not vary by age. For short-term use (no more than six weeks), it is safe for people 65 years and older, as well as for children from six to 17 years.
Tell your doctor if you are taking other medications for anxiety.
Many medications for anxiety can be dangerous if you stop taking them suddenly. They can cause a dangerous withdrawal reaction, which can include anxiety, insomnia, abdominal pain.
The transition from one of these drugs to Buspirone will not hinder the withdrawal reaction, because Buspirone does not act like these other medicines. Instead, you should gradually reduce the dose of drugs.
Your doctor should know if you have certain conditions so that he can decide if Buspirone is right for you. These include:
- Kidney disease
- Liver disease
- Drugs or alcohol abuse
- Pheochromocytoma (a rare tumor that causes high blood pressure)
In numerous online and anecdotal reports, it was said that some people abuse Buspirone to get a sense of euphoria.
Violation may result in:
- Nausea or vomiting
- Memory loss
- Lack of coordination
Take Buspirone only as directed by a doctor and keep it away from children, adolescents and anyone for whom the drug has not been prescribed.
Buspirone and pregnancy
Buspirone is not sufficiently tested to know if it is safe to take it during pregnancy.
Women should tell their doctor if they can become pregnant before taking Buspirone.
In addition, the drug can enter the breast milk, but it is unknown whether it is possible to take Buspirone during breastfeeding.
Buspirone: side effects
Tell your doctor if you have any side effects. The most common side effects are:
Less common side effects include:
- Stomach upset
- Dry mouth
- Problems with sleep
Serious side effects can occur. If you have any of these side effects, call your doctor immediately:
- Rash or urticaria
- Slow heart beat or fast heartbeat
- Blurred vision
- Abnormal and uncontrolled body movements
- Anger, hostility or confusion
- Stiffness of muscles
- Inability to urinate
Some medicines may affect the work of Buspirone, and Buspirone may affect other medicines that you take.
It is very important that your doctor knows about all the medicines that you take, including over-the-counter medications, vitamins and supplements.
Medications that are known to interact with Buspirone include:
- Selective serotonin reuptake inhibitors (SSRI), such as nefazodone (Serzone) and trazodone (Olepto)
- Warfarin (Coumadin)
- Drugs used to treat seizures, such as phenytoin (Dilantin) and carbamazepine (Tegretol)
- Benzodiazepines, which are used to treat anxiety and insomnia, such as diazepam (valium) and triazolam (Halcion)
- Muscle relaxants, such as cyclobenzaprine (Flexeril)
- Drugs used to treat fungal infections, including itraconazole (Sporanox, Onmel), itraconazole (Sporanox) and ketoconazole (Nizoral)
- Some antibiotics, including erythromycin (EES, E-Mycin, Erythrocin) and rifampin (Rifadin, Rimactane)
- Steroids such as prednisone
- The drug cimetidine (Tagamet)
- HIV-ritonavir (Norvir)
- Drugs used to treat high blood pressure and chest pain, including diltiazem (Cardizem) and verapamil (Calan, Verelan, Covera-HS)
- Antipsychotic drug haloperidol (Haldol)
Other interactions with buspirone
Buspirone can cause drowsiness and confusion.
Because of this, you should not drive a car or participate in any risky activities until you learn how Buspirone affects you.
You should also avoid drinking alcohol while taking buspirone.
Do not drink a large amount of grapefruit juice with Buspirone.
Buspirone is supplied in tablets at 5, 10, 15 or 30 milligrams (mg).
Tablets have the same mark in the middle, so if necessary, you can divide the tablet in half.
A typical dose starts with 7.5 mg every 12 hours. Your doctor may increase your daily dose by 5 mg every few days, if necessary.
The average daily dose is 20-30 mg per day in divided doses. The maximum daily dose is 60 mg.
Always take Buspirone at the same time each day with or without food.
Overdose Buspirone can cause:
- Blurred vision
If an overdose occurs, call the Toxicology Center or emergency room
Missed dose of buspirone
Take Buspirone exactly as prescribed by your doctor.
Do not stop taking Buxpiron yourself.
If you miss a dose of Buspirone, take it as soon as you remember. If it’s time for the next regular dose, skip it.
Do not double your dose to make up for the missed one.