Crestor is a trademark of rosuvastatin, a prescription drug used to treat high cholesterol.
Crestor is in a class of drugs known as statins that slow the accumulation of plaque in your arteries and reduce the level of “bad” cholesterol (LDL or low-density lipoproteins) and triglycerides in the blood.
At the same time, Crestor increases levels of HDL or high-density lipoproteins, also known as “good” cholesterol.
Currently, there is no general form of Crestor for consumers. The drug was approved by the Food and Drug Administration (FDA) in 2003 and manufactured by AstraZeneca.
Your doctor can prescribe Crestor to reduce the risk of a stroke, heart attack or other cardiac complications that may occur in patients with diabetes, coronary heart disease or other risk factors.
One use of Crestor is not enough: you will also have to lead a healthy diet and make other lifestyle changes.
People of Asian descent should know that they can absorb this drug faster than other people. As a result, your doctor may need to give you a lower, than usual, initial dose.
In some rare cases, people using Crestor developed a disorder in which the muscle tissue is destroyed, leading to kidney failure.
It is more likely if you are older, or if you have kidney disease or a low-activity thyroid (hypothyroidism), which is poorly controlled.
Tell your doctor if you drink two or more alcoholic beverages per day, have diabetes, a thyroid disorder, kidney disease, or liver disease.
It is important that you limit alcoholic beverages by taking Crestor, as a constant daily use of alcohol can increase the risk of developing liver problems.
Cross and Pregnancy
The FDA has a warning about using Crestor while you are pregnant, because it can harm your fetus.
It is also not recommended to take Crestor during breastfeeding, as it is not known whether this drug will get into breast milk.
Common side effects of Crestor include:
- Pain in muscles and joints
- Abdominal pain and nausea
- Increased sugar levels
- Memory loss
Tell your doctor right away if you have muscle pain or weakness, especially if it is accompanied by a fever, and if muscle problems continue after you stop taking Crestor.
Unexplained muscle pain, weakness, especially when it occurs with fever, may be a sign of a rare muscular problem that can lead to serious kidney problems.
If you are over 65 years old or have problems with the thyroid or kidneys, your risk of muscle problems will be greater.
Before you start using Crestor, your doctor should check your liver.
As soon as you start taking this medication, consult a doctor immediately if you notice any signs of liver problems, including:
- Feeling tired
- Loss of appetite
- Dark urine
- Abdominal pain
- Yellowing of the skin or eyes (jaundice)
There are a number of drugs that can interact with Crestor, so it is important that you provide your doctor with a complete list of all your medicines, vitamins and herbal supplements.
The following drugs may increase the risk of muscle problems if you take them with Crestor:
- Ciclosporin (Gengraf, Neoral or Sandimmune)
- Gemfibrozil (Lopid) should not be combined
- Fenofibric acid (Fibricor or Trilipix)
- Fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Trikor or Triglyde)
Other drugs that can increase the negative effects are HIV drugs, including:
- Atazanavir (Reietetz)
- Ritonavir (Norvir)
- Lopinavir / ritonavir (Kaletra)
- Saquinavir (Invirase)
Many other drugs should be combined with caution, such as warfarin (coumadin or yantovsky), cimetidine (tagamet), ketoconazole (nizoral) and birth control pills.
In addition, you should not take any other statins such as atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol) or simvastatin (Zocor or Vytorin).
When using Crestor, you should avoid eating foods high in cholesterol or fat, because this drug will not be as effective if you continue to eat a diet high in fat or high in cholesterol.
You should also avoid drinking alcohol because it can increase triglyceride levels and increase the risk of liver damage.
It is also important that you stop taking antacids from aluminum hydroxide and magnesium, such as Mylanta and Maalox, within two hours after using this drug.
Crestor and grapefruit
It is known that grapefruit and grapefruit juice interact with this medicine, which leads to serious problems.
Talk to your doctor about whether you need to restrict or eliminate all of the grapefruit products from your diet.
Crestor tablets range from 5 mg to 40 mg.
Your doctor will determine the appropriate dose based on your health status, age, race, and response to treatment, taking into account other drugs that you use.
After determining the appropriate dose, it is important that you do not stop taking this medication or exceed the prescribed amount, unless your doctor tells you about it.
If you think you have taken too much, call the emergency room or the toxicology center right away.
Most people forget to take their pills from time to time.
If this happens to you, take it as soon as you remember, if it does not happen within 12 hours after the next dose.
If this is the case, skip it and continue with your normal dosing schedule. Do not use a double dose.