Cyclosporine is the common name for prescription eye medicine. The drug is used to treat dry eyes.
The drug is also sold under the trademarks of Neoral, Sandimmune and Gengraf to reduce the risk of rejection of organ transplants.
Restoration is also used to treat a variety of rare eye conditions, including corneal melt, a serious condition often associated with autoimmune disorders such as psoriasis, rheumatoid arthritis or lupus.
Cyclosporine belongs to a group of drugs known as immunosuppressants, which limit the body’s ability to reject what it perceives as someone else’s tissue or organs.
The Food and Drug Administration (FDA) first approved Cyclosporin in liquid form under the Sandimmune trademark in 1983. Novartis produces Sandimmune.
The use of Cyclosporin in organ transplantation
Neoral, Sandimmune and Gengraf come in capsules or liquid formulations of Ciclosporin, which must be taken by mouth.
Doctors often prescribe this to reduce the risk of organ rejection in patients who underwent organ transplantation.
- You should not switch between dosage forms or brands of oral Cyclosporin, as each composition provides a different amount of Cyclosporine.
- People taking Gengraf are at increased risk of abnormal growth of new cells that can potentially become cancerous.
- An increased risk of skin cancer can occur in people with psoriasis – especially if you are taking methotrexate or other drugs that weaken the immune system.
- Even with standard doses, Cyclosporine can cause high blood pressure or kidney problems.
- Cyclosporine, prescribed for either rheumatoid arthritis or to prevent graft rejection, requires monitoring.
- Oral forms of Ciclosporin should be given only to qualified health professionals in the appropriate health facility.
You should not use Restasis if you are allergic to Cyclosporine or any other ingredients found in the drug.
Here are a few important reminders about Restasis:
- Try not to touch the tip of the applicator with your hands, to any part of the eye or to any other object.
- Do not wear contact lenses when applying drops to the eyes.
- It is normal to use artificial tears when using Restasis, but do not forget to first apply Restasis and wait 15 minutes before using the following eye drops.
Pregnancy and Cyclosporin
There is some evidence that Cyclosporine can harm a developing fetus.
Your doctor will determine if you should use this medication.
Cyclosporin was found in breast milk. Experts do not recommend using this drug during breastfeeding.
It is always useful to talk with your doctor about all the medicines that you take, if you are pregnant, you can get pregnant or breastfeed.
Side Effects of Cyclosporine
Common side effects
Tell your doctor if any of the following side effects become serious or persistent:
- Pain, burning in the eyes
- Eyes flooded with blood
- Feeling, something hit the eye
- Itching and blurry vision
Serious side effects
The main serious side effect of using Restasis is the allergic reaction to the drug.
Call your doctor right away if you have any such reaction.
Tell your doctor about all prescription, non-prescription, illegal, recreational, herbal, food or dietary supplements that you are taking.
In general, Restasis does not really have many interactions with other drugs.
But if you take capsules or a solution of Cyclosporine, you can ask your doctor or pharmacist about Restasis before using it.
Cyclosporine and alcohol
Alcohol can cause your eyes to dry even more, defeating the purpose of using Restasis.
Therefore, if possible, try to avoid or limit the use of alcohol when using Restasis.
You should avoid the use of grapefruit and grapefruit juice when using drugs containing Ciclosporin.
Dosage of Ciclosporin
Respiratory eye drops reach 0.05 percent.
For dry eyes, a typical dose is one drop in each eye twice a day.
As a rule, an overdose of eye drops is unlikely.
But if you suspect an overdose, immediately contact a toxicology center or an emergency room.
Missed dose of Ciclosporin
If you miss a dose of Cyclosporine, try to take it as soon as you remember.
But skip it if it’s time for the next scheduled dose.
Do not take additional medication to make up for the missed dose.