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Diclofenac

Diclofenac is the generic name for a prescription drug. Produced by trademarks: Voltaren, Pennsaid, Solaraze, Zipsor, Cataflam and Zorvolex.
Diclofenac is usually used to relieve pain, swelling, or inflammation caused by such traumas and conditions as osteoarthritis, rheumatoid arthritis, painful menstruation, migraines and ankylosing syndrome.

Diclofenac belongs to the group of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). They work by inhibiting a certain type of prostaglandin, which causes inflammation.

Diclofenac was first approved in 1998 by the Food and Drug Administration (UKP & L) under the trademark Voltaren. Originally it was manufactured by Novartis.

Contraindications for use

The drug has two main contraindications:
Diclofenac may increase the risk of heart disease and trigger a heart attack, stroke and cause coagulability – all of which can lead to death. Seek medical attention immediately if you experience signs of a stroke or heart problems, such as chest pain, shortness of breath, speech problems, or other unusual symptoms.
Diclofenac can damage the walls of the stomach, exposing you to the risk of ulcers or heartburn. Put and the fame of your doctor if you have stomach pain, nausea, black or too tight a stool.
If heart surgery is to be performed, especially bypassing the coronary artery (SCA), the drug should be discontinued.
If you suffer from a condition known as the “triad of aspirin”, in which you suffer from allergic reactions to aspirin or other components of the drug, polyps develop or grow in the nose, the drug should be discontinued.
It is also necessary to consult with your doctor if you:

  • Have ever had asthma or a severe allergic reaction to aspirin or other constituents of the drug
  • With congestive heart failure, a recent heart attack or high blood pressure
  • There is a fluid retention in the body
  • There are bleeding sores
  • Smoking or alcoholism
  • There are problems with the liver or kidneys
  • Any condition that includes abnormal bone marrow activity
  • Any bleeding disorders, including poor blood clotting or blood cell abnormalities

Diclofenac in old age

If you are older than middle age, you should be more careful when taking diclofenac. It has a stronger effect on people of age. It can disrupt the coordination of the movement, which will put you at risk of falling and other dangerous events.
In general, the drug can cause severe drowsiness, confusion, dizziness, poor coordination and serious stomach problems in the elderly.

Pregnancy and diclofenac

Since the risk of damaging the unborn child changes during pregnancy, diclofenac is dangerous in two cases:
In the first 29 weeks of pregnancy, when taking diclofenac, there is a risk of harm to the fetus.
During or after the 30th week of pregnancy, the drug can cause a birth defect, causing a blockage of a large artery in the heart of the child. Hence the conclusion is that taking diclofenac during pregnancy is only if there are no other options.
Regardless of this, you should inform your doctor about pregnancy or if you are planning to become pregnant before taking this medication.
You should also notify your doctor if you are breast-feeding or plan to breast-feed. Diclofenac affects breast milk, and mothers should avoid taking this medication while breastfeeding.

Side Effects of Diclofenac

Common side effects of diclofenac:
Although these side effects of the drug are not so common, they can have serious consequences.
Stop taking the medication and tell your doctor right away if you have the following symptoms:

  • Problems with the stomach, including gas, bloating, pain, cramps, constipation and diarrhea
  • Stomach upset and / or bleeding in the stomach, esophagus or intestine
  • Headache and ringing in the ears
  • Rashes on the skin

Serious side effects

Stop taking the medication and tell your doctor right away if you have the following symptoms:

  • Damage to the liver or inflammation of the liver (watch for yellowing or whitening of the eyes, swelling of the abdomen or lower limbs)
  • Low blood pressure (one of the signs of low blood pressure – dizziness with a sharp rise from the place)
  • Blood disorders such as low platelet count, decreased hemoglobin, and decreased bone marrow activity
  • Congestive heart failure (watch for swelling of the lower extremities, shortness of breath, excessive fatigue)
  • Strong and potentially life-threatening skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis (tell your doctor about any skin disorders, seek medical help immediately if you have any dramatic or severe skin reactions)
  • In severe cases, diclofenac can cause a fatal liver condition known as fatal fulminant hepatitis.

Interaction of diclofenac with other drugs

Diclofenac interacts with many different drugs. It is necessary to warn the doctor and pharmacist about all medications that you take.
This includes not only all your traditional medicines, but also products that may not be medicines, such as: vitamins and other nutritional supplements (nutritional cocktails, protein powders, etc.).
Diclofenac is not compatible with such drugs as:

  • Apixaban (Elixis)
  • Ketorolac
  • Nasal Spray Ketorolac (Sprix)
  • Methotrexate (Trexall)
  • Premetrexed (Alimta)
  • Pirfinidone (Esbriet)

If you are taking any of the following, consult your doctor to replace diclofenac with another drug:

  • Blood solvents such as fondaparinux (Arixtra), dabigatran (Pradaxa) warfarin (Jantoven, Coumadin) or heparin
  • Antidepressants, such as citalopram (Celexa), paroxetine (Paxil) or escitalopram (Lexapro)
  • Aqueous pills such as hydrochlorothiazide (Esidrix, Microzide), chortalidone (Thalitone) or chlorothiazide (diurel)
  • Beta-blockers, such as acebutolol (Sectral), bisoprolol (zebit), atenolol (Tenormin), esmolol (Brevibloc) or carvedilol (Coreg)
  • Including: celecoxib (Celebrex), naproxen (Aleve, Naprosyn), meloxicam (Mobic), nabumeton (Relafen) or etodolak (Lodine)
  • Diabetic drugs, called sulfonylureas, such as glimepiride (Amaryl), glyburide (DiaBeta, Micronase, Glynase) and glipizide (Glucotrol)

Interaction with alcohol

You should exclude alcohol while taking diclofenac. This can increase the risk of bleeding in the stomach and lead to kidney damage.

Diclofenac and grapefruit juice

Whether grapefruit interacts with diclofenac remains unknown. Therefore, your best bet is to avoid all citrus fruits while taking diclofenac.

Diclofenac Dosage

Diclofenac is produced by several companies, therefore, depending on the reason for taking, the recommended dose can be from 50 mg to 100 mg at intervals of 8 to 12 hours.
The maximum daily dose should not exceed 225 mg per day.
Always take the drug with plenty of water or along with food, or milk, since the drug can have a severe effect on the stomach.

Overdose

If you have symptoms of an overdose, immediately go to the emergency room.

Missed admission

If you miss the drug, drink it as soon as you remember.
However, if you remembered by the time of the next dose, do not double the dose to make up the pass.

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