Fluconazole, marketed under the trade name Diflucan, is a drug used to treat fungal infections in the mouth and throat and fungal infections in women.
Fluconazole belongs to a group of drugs known as antifungal agents that act to prevent the fungus from creating its own form of cholesterol based on plants.
Fluconazole was approved by the Food and Drug Administration (UPK & L) under the Diflucan trademark in 1990 and manufactured by Pfizer.
It is recommended to refrain from taking if you are allergic to fluconazole or any of its inactive ingredients.
If you take medicines that affect your heart, you should also refrain from taking fluconazole.
In addition, if you have serious problems with the kidneys, your body may not withdraw the drug as quickly as it costs.
In this case, the doctor should prescribe the dosage individually.
Be sure to tell your doctor that you have kidney problems before taking this medication. People who are on dialysis should receive a full dose of fluconazole only after they have completed the dialysis procedure.
Consult your doctor before taking fluconazole if:
- You take medications that change the heart rate or the patency of the vessels, such as erythromycin, orac (pimozide), or quinidine
- There are kidney problems
- You are pregnant
In addition, if you are allergic to azoles (a building block of a certain class of antifungal drugs, including fluconazole), you should not take fluconazole.
It should also be noted that people with a certain sensitivity should be careful with various dosage forms of fluconazole.
For example, people who may have inherited certain genetic conditions, including intolerance to certain sugars, such as glucose-galactose, laplase lactase or sucrose, should avoid Diflucane capsules because they contain lactose.
People with glycerin sensitivity should avoid fluconazole syrups, because glycerin can cause unpleasant symptoms such as diarrhea, stomach discomfort or headaches.
Pregnancy and fluconazole
In general, it is not recommended, intake during pregnancy.
Fluconazole can damage the fetus and should be taken only in situations where there are no other safe options.
Regardless, you must tell your doctor if you are pregnant or plan to become pregnant before taking this medication.
Studies have shown that fluconazole is transmitted with breast milk, so tell your doctor if you are breast-feeding or plan to breast-feed.
Side effects of fluconazole
Headache is the most common side effect of fluconazole. Other side effects include: nausea, diarrhea, vomiting, rash and stomach pain.
Serious side effects of fluconazole:
- Changes in heart rate or electrical activity in the heart
- Renal insufficiency and inflammation, including increased levels of liver enzymes and yellowing of the skin, nails and white eyes (jaundice)
- Swelling of the lips, mouth and tongue (angioedema)
- The drop in the number of white blood cells or the number of platelets
- Labored breathing
- High triglycerides, low levels of potassium in the blood
- Severe and potentially life-threatening skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis
Rare side effects of fluconazole
Fluconazole may cause some unpredictable side effects, including baldness and dizziness.
Interaction with other drugs.
Fluconazole interacts with a large number of drugs and can increase their level in the blood, which causes dangerous reactions.
Be sure to inform the doctor about all the medications that you take.
This includes not only traditional medicines, but also vitamins and other nutritional supplements (nutritional cocktails, protein powders, etc.)
You should not take fluconazole, along with such drugs:
- Hismannal (astemisole)
- Erythromycin-containing drugs, including drugs containing erythromycin base, eluyromycin-ethyl succinate, erythromycin lactobionate or erythromycin stearate
- Ibtulid, desopyramide, Prosthal, Prokan or Prokanbid (procainamide)
- Lozol (indapamide)
- Neupuvant (pentamidine)
- Orak (pimozide)
You should consult your doctor about options for replacing fluconazole if you are taking the following:
- Drugs for irregular heart rhythms, such as Cordarone or Amidarone, Betapace or Betapace AF (sotalol), Ticosin or dronedarone.
- Medications for mood and / or depression, such as Pamelor (nortriptyline), Prozac (fluoxetine), Buspar (buspirone), Cilexa (citalopram), and Abiliphy (aripiprazole)
- Statins for cholesterol, such as Lipitor (atorvastatin), Zocor (simvastatin) and Mevacor (lovastatin)
- Estrogen-containing drugs, for birth control and hormone replacement therapy
- Foradyl or Pfororomist (formoterol)
- Koreg (carvedilol)
- Migergot or Kafergot (ergotamine) and Migranal (dihydroergotamine)
- Antibiotics such as biaxin (clarithromycin), Avelox (moxifloxacin), and Citromax (azithromycin)
- Some cancer drugs, such as Doxil or Adriamycin (doxorubicin), Cometric (cabozantinib), Inlita (axitinib), Bosulif (Bosutinib), and Votrient (pazopanib)
- Psychiatric drugs, such as Haldol (haloperidol) and Geodon (ziprasidone)
- Coumadin (warfarin)
Interaction with alcohol.
You should avoid or limit the use of alcohol while taking fluconazole.
Since both components alone can cause headaches and discomfort in the stomach, and alcohol consumption with fluconazole may worsen these side effects.
Fluconazole and grapefruit juice
The liver absorbs fluconazole and grapefruit juice the same way.
Grapefruit juice slows the process of fluconazole withdrawal from the body, which can cause an increase in the level of fluconazole in the blood.
Therefore, you should avoid eating grapefruit and grapefruit juice while taking fluconazole.
Dosage of fluconazole
Fluconazole is available in the form of tablets, liquids and ointments.
You should take your doctor’s prescribed dosage every day, even after the symptoms disappear, unless the doctor says otherwise.
To treat fungus in the mouth and fungus, known as thrush, your doctor may prescribe 200 mg on the first day and then 100 mg per day for at least two weeks.
People with fungal infections of the esophagus may take 200 mg on the first day, and then 100 mg per day for at least three weeks.
After recovery, you should continue to take fluconazole for at least two weeks. Depending on how much the drug affects you, the doctor can increase the daily dose to 400 mg per day.
To treat yeast infections of the vagina, a single dose of 150 mg is sufficient.
To help avoid or prevent fungal infections in the treatment of patients with bone marrow transplantation, the usual dose is 400 mg per day.
People with a type of meningitis (usually observed in people with AIDS) are usually prescribed 400 mg or more of fluconazole for the first day, and then 200 mg per day.
Depending on how your body reacts to the medicine, your doctor can increase the dosage to 800 mg per day.
The doctor may also prolong the use of fluconazole until the results of the test for your cerebral fluid (cerebral spinal fluid) are negative.
The dosage of fluconazole usually depends on the weight of the child, so seek help from your doctor.
Overdose with fluconazole
If you observe symptoms of an overdose, immediately contact the emergency department.
Missed administration of fluconazole.
It is not recommended to stop taking it yourself. Only in consultation with your doctor.
If you miss the drug, drink it as soon as you remember.
However, if you remembered by the time of the next dose, do not double the dose to make up the pass.