Glyburide is the general version of the branded drug DiaBeta.
It is used in conjunction with diet and exercise to help control blood sugar in people with type 2 diabetes.
If you have type 2 diabetes, your body does not produce or does not use the hormone normally, so it can not control the amount of sugar and glucose in the blood.
Glyburide is in a class of drugs that stimulate the production of hormone insulin.
Taking glyburide, along with maintaining a healthy lifestyle, can reduce the risk of developing serious or dangerous conditions for human life.
They can include cardiovascular diseases, such as blood circulation problems; nerve damage; kidney disease.
The Food and Drug Administration (FDA) approved glyburide in 1984.
You should not take glyburide if you have diabetic ketoacidosis (a dangerous condition that can occur in the absence of sugar in the blood).
Before taking this medication, tell your doctor if you have or have ever had:
- Deficiency G6PD (hereditary state of the enzyme)
- Hemolytic anemia (absence of erythrocytes)
- Heart, kidney or liver disease
- Nerve disorder that affects the body’s function
You should not take this medication if you are taking Tracepher, because this can increase your risk of developing liver problems.
Before the operation, including the dental procedure, tell your doctor or dentist that you are taking glyburide.
Some diabetes medications can increase the risk of serious heart problems.
Tell your doctor if you experience an illness, fever, trauma or unusual stress while taking glyburide, because they can change the blood sugar level and the dosage you need.
Glyburide can change the level of sugar in the blood.
You should know the symptoms of high (hyperglycemic) and low blood sugar and be prepared for their treatment.
Your doctor will probably want to regularly check the glucose level while you are taking glyburide.
This medicine helps to control blood sugar, but does not cure diabetes. Do not stop taking glyburide without first talking to your doctor.
Always wear a bracelet with a diabetic ID to ensure proper treatment in the event of an emergency.
Pregnancy and Glyburid
Harm to the unborn child from taking the drug can not be ruled out.
Tell your doctor if you are pregnant or plan to become pregnant.
Do not breast-feed while using this medication.
Gestational diabetes and glyburide
Glyburide is sometimes used to treat women with a form of diabetes that occurs during pregnancy (known as gestational diabetes).
However, in some studies, glyburide can not be as safe or effective as injectable insulin.
Other studies have shown that women with gestational diabetes may require higher doses of glyburide.
Talk with your doctor about the potential risks and benefits of using this medication.
Tell your doctor if any of the following side effects become serious or persistent:
- Pain in muscles or joints
- Blurred vision
Serious side effects
Immediately consult your doctor if you experience the following serious side effects:
- Dark urine
- Bright chair
- Yellowing of eyes or skin
- Sore throat
If you have one of the following conditions and you can not contact a doctor, you may need emergency medical attention:
- Pain in the upper right side of the abdomen
- Slurred speech
- Severe weakness
- Unusual bleeding or bruising
- Swelling of the eyes, face, lips, tongue, or throat
Tell your doctor about all the medicines that you take, especially:
- Angiotensin converting enzyme (ACE) inhibitors such as Lotensin, Capoten, Vasotec, Monopril, Prinivil, Zestril, Univasc, Aceon, Accupril and Mavik,
- known as quinolone or fluoroquinolone such as cinoxacin (Cinobac), enoxacin (Penetrex), gatifloxacin (tequin), levofloxacin, lomefloxacin (Maxaquin), (Avelox), nalidixic acid (NegGram), norfloxacin (noroxin) (Floxin), sparfloxacin Zagam) or trovafloxacin and alatrofloxacin (Trovan)
- and other non-steroidal anti-inflammatory drugs such as (Advil, Motrin) and (Aleve, Naprosyn)
- Blood solvents such as warfarin, (Tenormin), (Normodyne), (Lopressor, Toprol XL), (Corgard) and propranolol
- Boscentan (Tracleer)
- Amlodipine, (Cardizem, Dilacor, Tiazacid.), Felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), (Adalat, Procardia), nimotipin, nisoldipine (Sular) and Isoptin
- Biaxin, an antibiotic
- Cold medicines
- Contraceptives such as contraceptive pills, patches, rings, implants, and injections
- (Neoral, Sandimmune), an immunosuppressant
- Preparations for the treatment of diabetes mellitus
- Disopyramide (Norpace), a heart drug
- Diflucan against fungal infections
- Hormone replacement therapy
- MAOIs, such as isocarboxazid (Marplan), fenelzin (Nardil), selegiline (Eldepryl, Emsam, Zelapar) and tranylcypromine (Parnate)
- Medications such as Sarafem and others
- Miconazole (Monistat)
- Dexone, Medrol and Deltasone
- Probenecid (Benemid), for the prevention or treatment of certain types of arthritis
- Salicylate analgesics, such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (dolobid) magnesium salicylate (Doan’s, etc.) and salsalat (Argesic, Disalcid, Salgesic)
- Sulfa, including antibiotics such as cotrimoxazole (Septra); and drugs from arthritis (Azulfidine)
Glyburide and alcohol
Avoid drinking alcohol while taking glyburide, as it can lower blood sugar and increase the risk of side effects.
Although rarely, drinking alcoholic beverages while taking glyburide can cause headache, redness, nausea, vomiting, chest pain, weakness, blurred vision, sweating, gasps, mental confusion, or difficulty breathing.
Gliburid and other interactions
Glyburide can make your skin more sensitive to sunlight. Avoid unnecessary exposure to the sun and tanning beds.
Also, wear protective clothing and use sunscreen when you are on the street.
This medicine may also make you drowsy or dizzy.
Do not control or perform any actions that require vigilance until you are sure that you can do it safely.
Dosage of Glyburide
Glyburide is available as a tablet and is usually taken through the mouth with breakfast or first meal of the day.
This medication is usually taken once a day. However, some people can take it twice a day.
Carefully follow the directions when taking glyburide. Do not take more or less medicine than prescribed.
Your doctor can start with a low dose and gradually increase it if necessary.
If you suspect an overdose, you should immediately contact a toxicology center or an emergency room.
Missed dose of Glyburide
Ask your doctor what to do if you forget to take a dose of glyburide and write down these instructions.
Usually, if you miss a dose, take it as soon as you remember.
However, if it’s time for the next dose, skip it and continue your usual dosing schedule.
Do not take additional medication to compensate for the missed dose.