Ibuprofen sold by the trade names Advil, Motrin and Ibuprin is a medicine used to relieve pain, swelling and inflammation.
Motrin and Advil can be purchased without a prescription in tablets at 200 milligrams (mg), whereas higher doses require a prescription.
Ibuprofen, available in tablets and capsules, is also found in combination with other products sold over the counter for cough, cold and migraine.
In certain situations, it is prescribed in liquid form, that is, intravenously.
Ibuprofen refers to a group of drugs known as non-steroidal anti-inflammatory drugs, or NSAIDs that act by inhibiting prostaglandins, chemicals that can cause inflammation in the body.
The Food and Drug Administration (FDA) initially approved ibuprofen under the Motrin brand in 1974. It was made by McNeil.
Ibuprofen and Tylenol (acetaminophen)
Tylenol (acetaminophen) provides relief of pain, but, unlike NSAIDs such as ibuprofen, it does not affect inflammation.
This is because Tylenol works differently than ibuprofen and NSAIDs. To date, Tylenol’s method is not entirely clear, but it is believed that it reduces pain by acting on pain receptors in the brain.
Unlike ibuprofen, Tylenol does not cause activity in the stomach and does not cause pain or acid reflux.
And, like most NSAIDs, including ibuprofen, Tylenol reduces fever.
Ibuprofen and Aleve (Naproxen)
Ibuprofen and Aleve (Naproxen) are similar in that they contain the same basic chemical building block.
In addition, they are both available without a prescription in low doses and on prescription at higher doses.
However, the effects of ibuprofen are not as long as that of Aleve, so you will have to take it every four to six hours (up to six times a day).
Aleve should be taken only three times a day or every eight hours.
Contraindications for use
The main contraindications:
- Ibuprofen may increase the risk of heart disease and cause a heart attack, stroke and clotting, which can lead to death.
- Ibuprofen can damage the walls of your stomach, exposing you to the risk of stomach ulcers and heartburn.
- If you are allergic to ibuprofen or any of its inactive ingredients, it is worth to refrain from taking.
- People who are undergoing heart surgery, especially a procedure called bypassing the coronary artery (CABG), should not take ibuprofen.
You should also be careful when taking ibuprofen and consult a doctor if:
- Have you ever had asthma or a severe allergic reaction caused by a reaction to taking aspirin or other NSAIDs
- You have chronic heart failure
- Extremely low erythrocyte count (severe anemia)
- Increased pressure in the skull (increased intracranial pressure or PMS)
- Recent heart attack
- Systemic lupus erythematosus (SLE)
- Any bleeding disorders, including slow or poor blood clotting, blood cell abnormalities
Ibuprofen and the elderly
Elderly people should be very careful when receiving. Side effects caused by anesthetic NSAIDs, such as ibuprofen, when they are taken by elderly patients, can lead to impaired coordination and lead to a fall.
In general, NSAIDs that are dispensed without a prescription and prescription can cause severe drowsiness, confusion, dizziness, loss of balance and serious stomach problems in the elderly.
However, low doses of ibuprofen are generally a safer choice for older patients than most other painkillers.
Ibuprofen for dogs
Ibuprofen is unsafe to give to a dog.
Talk to your veterinarian about other pain killers that will be safer for your animal, since ibuprofen (and other pain killers) can cause life-threatening digestive, kidney or liver problems.
However, some pain killers can safely relieve pain from tumors in dogs, as in humans, and usually do not cause any undesirable side effects.
Anesthetics, safe for dogs, include:
- Previscox (froxoxib)
- Metacam (meloxicam)
- Novoks, Rimadyl (carprofen)
- Previscox (froxoxib)
- Zubrin (tepoxaline)
Pregnancy and ibuprofen
Since the risk of harm to the unborn child depends on the period of pregnancy, ibuprofen refers to two categories:
During the first 29 weeks of pregnancy ibuprofen carries a certain risk of harm to the fetus.
During the 30 weeks and after, ibuprofen should be taken only in situations where there are no safer options.
Ibuprofen can cause a birth defect, creating a serious problem with the artery that nourishes the child’s heart.
Ibuprofen also affects breast milk, and mothers should avoid taking this medication during breastfeeding.
Regardless of whether you are pregnant or plan to become pregnant, you should tell your doctor before taking this medication.
You should also notify your doctor if you are breast-feeding or plan to breast-feed.
Common side effects of ibuprofen:
- Abdominal pain
Serious side effects of ibuprofen:
- Damage or inflammation of the liver
- Low amount of platelets
- Blood in the urine
- Urinary tract infection
- The condition in which the bone marrow can not make enough white blood cells, known as agranulocytosis
- Low amounts of red blood cells or anemia
- Strong and potentially life-threatening skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis
- Heart Attack
- High blood pressure (usually a greater risk with prolonged use and in taking some other medicines)
- Kidney damage
Interaction of ibuprofen with other drugs
It is known that ibuprofen interacts with many different drugs. It is always important to inform your doctor or pharmacist about the recreational, herbal, nutritional or dietary preparations that you are taking.
It is not recommended to take ibuprofen if you take aspirin to dilute blood and protect the heart.
This is due to the fact that ibuprofen can block the effect of dilution of blood with aspirin. It is recommended to avoid taking ibuprofen, or take ibuprofen one hour before taking aspirin or eight hours after.
If you are taking any of the following drugs, consult your doctor about the appointment of an alternative to ibuprofen:
- Aspirin (both tablets and suppositories)
- Alka-Seltzer (aspirin / citric acid / sodium bicarbonate)
- Oncological drugs, called pathogenic modifying antirheumatic drugs
Serious drug interactions
Ibuprofen interacts with hundreds of drugs, including:
- Blood solvents such as fondaparinux, pradaxa (dabigatran) and warfarin
- Antidepressants, including citalopram, paroxetine and escitalopram
- Aqueous drugs (diuretics), such as esidrix, hydrochlorothiazide, thalton and chlorothiazide
- Beta-blockers, such as acebutolol, bisoprolol, atenolol carvedilol
- Other NSPPs, such as celecoxib, naproxen, nabumethon, etodolac, ketorolac
If you take ibuprofen for a long time, combined with certain medications for blood pressure, called ACE inhibitors and ARBs, you may notice that your blood pressure is worse controlled.
Examples of these drugs include:
- Vasotec (enalapril)
- Mavik (trandopril)
- Accupril (hinapril)
- Monopril (fosinopril)
- Avapro (irbesartan)
- Atacand (candesartan)
- Cosaar (losartan)
- Benicar (omsartan)
It is important to note that some herbal and other supplements can help liquefy the blood and / or increase blood pressure.
The use of such supplements when taking ibuprofen may increase the risk of bleeding and / or increase blood pressure.
Examples of such plant products include:
- Gingko biloba
- Green tea
Ibuprofen and alcohol
It is not recommended to use ibuprofen together with alcohol, since during the intake of ibuprofen it may increase the risk of bleeding in the stomach and even contribute to kidney damage.
Ibuprofen and grapefruit juice
Since your liver does not treat grapefruit juice in the same way as ibuprofen, there are no contraindications to their joint use.
Dosage of ibuprofen
Ibuprofen is dispensed without a prescription. Produced in tablets or capsules of 200 mg. Under the prescription, in doses – 400, 600 and 800 mg.
For adults and children over 12 years of age, the usual dose of ibuprofen is one to two tablets or capsules every four to six hours. As needed.
Do not take more than 2,400 mg (12 capsules or tablets) of ibuprofen daily.
Take the drug during or after a meal.
For pain in the bones and joints of osteoarthritis and rheumatoid arthritis, doses range from 300 mg, 400 mg, 600 mg, or 800 mg every six to eight hours, with no more than 3.2 g or 3200 mg daily.
If you have symptoms of an overdose, immediately go to the emergency room.
Missed drug intake.
If you miss taking ibuprofen, drink it as soon as you remember.
However, if you remembered by the time of the next dose, do not double the dose to make up the pass.