Lisinopril is a common form of the branded drug Zestril, a medicine designed to treat high blood pressure.
Doctors also prescribe lisinopril in combination with other drugs to treat congestive heart failure.
Lisinopril belongs to a class of drugs called angiotensin-converting enzyme inhibitors, or ACE inhibitors.
It works by dilating the blood vessels, which allows blood to flow more smoothly and allows the heart to function more efficiently.
Reducing blood pressure, Lisinopril also helps reduce the risk of stroke and heart attack.
The Food and Drug Administration (FDA) first approved lisinopril in 1987.
The pharmaceutical company Merck developed Lisinopril under the trademark Prinivil. In 2002, the FDA approved the general Lisinopril.
If you take medications or insulin for diabetes, carefully monitor blood sugar levels while taking lisinopril, especially during the first month of use.
The combination of these drugs can lead to a decrease in the level of sugar in the blood.
It is also important to know about any signs of infection, such as sore throat or fever, which may indicate a problem with your white blood cell count.
Before you start taking lisinopril, be sure to tell your doctor if you are planning any operations, including dental.
Tell your doctor if you have angioedema, a condition that causes problems with swallowing or breathing, and a painful swelling in various parts of the body, including the face, throat, eyes, hands, feet, ankles and lower legs.
You should also tell your doctor if you have diabetes and you are taking aliskiren (Tekturna, Amturnide, Tekamlo, Tekturna HCT).
Your doctor also needs to know if you have ever:
- Heart or kidney disease
Pregnancy and lisinopril
There is strong evidence that lisinopril can harm an unborn baby.
Make sure your doctor knows if you are pregnant or you can become pregnant before taking lisinopril.
If you become pregnant with Lisinopril, call your doctor immediately.
It is not known whether a drug enters the breast milk of a woman, but to be safe, women who breastfeed should stop breastfeeding (or not take lisinopril).
Studies show that lisinopril is safe and effective for children older than 6 years and for adolescents. There is insufficient evidence that this is safe for young children.
Lisinopril Side Effects
Common side effects of lisinopril include:
- Extreme fatigue
- Runny nose
- Low craving for sex
Serious side effects can also occur. If you have any of these side effects, call your doctor immediately:
- Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or legs
- Unpleasant breathing or swallowing
- Signs of infection such as fever, sore throat and chills
- Yellowing of the skin or eyes
- Thoracic pain
Some drugs may interfere with the work of lisinopril, and lisinopril may also affect other medications.
It is very important that your doctor knows everything that you are taking, including any over-the-counter medicines, herbs or supplements, and illegal medicines.
Drugs that interact with lisinopril include:
- Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin (indocin)
- Diuretics (“water tablets”)
- Additives of potassium
- Diabetes medications such as insulin and aliskiren (Tekturna, Amturnide, Tekamlo, Tekturna HCT)
- Antidepressant lithium (Eskalith, Lithobid)
- Other ACE inhibitors
Lisinopril and alcohol
People taking lisinopril are advised to avoid drinking alcohol.
Alcohol can also reduce blood pressure and may increase the risk of certain side effects of lisinopril.
It is important to talk to your doctor before using any salt substitutes that contain potassium when you take Lisinopril.
Your doctor may also tell you to follow a diet low in salt or low in sodium.
It is important to closely monitor these instructions.
Dosage of lisinopril
Lisinopril is a pill that you take orally. It is available in various doses, from 2.5 mg (up to 40 mg).
Usually, lisinopril is taken once a day, at about the same time every day.
Your doctor will probably prescribe a low dose of the drug and gradually increase it over time.
For people with high blood pressure, a typical dose of lisinopril is 20 to 40 mg per day.
When treating heart failure, the effective dose of the drug is from 5 to 40 mg per day.
For people who have had a heart attack, the first dose of lisinopril is 5 mg. After 24 hours you will receive another 5 mg. After 48 hours, you take 10 mg per day for six weeks.
For children, the usual initial dose of lisinopril is up to 5 mg per day.
Overdose with lisinopril
Too much Lisinopril will most likely result in low blood pressure.
Symptoms of an overdose of lisinopril may include:
If you or someone else has overdose symptoms, call the Toxicology Center
If someone collapses or does not breathe, call 911.
Missed dose of lisinopril
Continue to take Lisinopril, even if you feel good. Do not stop taking lisinopril without first talking to your doctor.
If you miss a dose of Lisinopril, take it as soon as you remember.
Forget the missed dose if it’s time for the next scheduled dose.
Do not double the dose to make up the missed one.