Pantoprazole is a drug prescribed as a short-term treatment for gastroesophageal reflux disease (GERD).
GERD is a condition in which a reverse acid flow from the stomach causes heartburn, and sometimes damage to the esophagus.
PPI, such as Pantoprazole, block the production of acid produced in the stomach.
Pantoprazole can also be used for a longer period of time to maintain or heal erosive esophagitis and to treat conditions in which the stomach produces too much acid, for example, Zollinger-Ellison syndrome.
Pantoprazole was originally approved by the Food and Drug Administration (FDA) in 2000 and manufactured by the pharmaceutical company Pfizer.
In 2013, Teva Pharmaceutical Industries Ltd. (TEVA) and SunPharmaceuticalIndustriesLtd. was ordered to pay $ 2.15 billion to Pfizer for settling cases of unauthorized sales of pantoprazole.
Pantoprazole should not be used to immediately relieve the symptoms of heartburn.
Do not take Pantoprazole if you are allergic to any other benzimidazole drugs, such as Albendazole (Albenza) or mebendazole (Vermox).
Long-term use of pantoprazole may complicate the body’s absorption of vitamin B-12, which can lead to a B-12 deficiency.
Using PPI can also increase the risk of fractures in your wrists, hips, or spine. However, in 2010, the FDA decided that there was insufficient evidence of a fracture risk in order to earn a warning.
It has been shown that the expanded use of pantoprazole causes gastric cancer in animal studies, but researchers are not sure whether the drug has the same effects in humans.
Pantoprazole can be used by children aged five years and older for up to eight weeks to heal acid-related damage to the esophagus.
Tell your doctor if you are allergic to any ingredient in Pantoprazole. You can ask your pharmacist to make a list of ingredients
Pantoprazole and magnesium
A low level of magnesium can also occur in people taking Pantoprazole for at least three months.
Tell your doctor if you have ever had low magnesium in your blood.
A low level of magnesium can lead to serious undesirable phenomena, such as:
- Muscle spasms
If you have a low level of magnesium when using Pantoprazole, your doctor may advise you to take a magnesium supplement or stop treatment.
Pantoprazole and pregnancy
Tell your doctor if you are pregnant, plan to become pregnant, or breastfeed before taking Pantoprazole.
Although there is no evidence that the use of pantoprazole is harmful during pregnancy, it is recommended that the drug is used only during pregnancy as needed, when there are no other options.
The manufacturer recommends that, because of the possibility of serious adverse reactions in infants, mothers using Pantoprazole may need to stop breastfeeding or stop using the drug.
Side Effects of Pantoprazole
The most common side effects of Pantoprazole are:
- Joint Pain
You should immediately call your doctor or get emergency medical help if you experience the following side effects:
- Skin coloring or peeling
- Swelling of the eyes, face, lips, mouth, throat, or tongue
- Muscle spasms
- Uncontrolled shaking of body parts
- Difficulty breathing or swallowing
- Irregular, fast or pounding heartbeat
- Excessive fatigue
- Severe diarrhea
- Abdominal pain
Before taking Pantoprazole, tell your doctor and pharmacist of all the medicines that you take (including vitamins and herbal supplements).
Pantoprazole should not be taken with atazanavir (Reyetaz) or nelfinavir (Viracept), which are drugs used to treat HIV and AIDS.
Other drugs that can interact with Pantoprazole include:
- Ampicillin (Omnipen, Principe, Amsil)
- Warfarin (Kumadin, Jantoven)
- Digoxin (lanoxin, lanoxicapa)
- Antifungal agents such as ketoconazole (nizoral), itraconazole (sporanox), and voriconazole (Vfend)
- Iron supplements / iron sulfate (Feosol, Mol-Iron, Fergon, Femiron)
- Methotrexate (Trexall)
- Delavirdine (Rescriptor)
Dosage of Pantoprazole
Pantoprazole is supplied as a granule, a sustained-release oral suspension available in a single dose (40 mg) and as a sustained-release tablet, available in two doses (20 mg and 40 mg).
It is also available in intravenous (IV) solution for use in a hospital.
Typically, your doctor will prescribe 40 mg daily for four to eight weeks of treatment. The medicine should be taken at about the same time every day.
Take Pantoprazole for the entire prescribed period of time, as your symptoms can improve before your condition is completely cured.
The tablet form of Pantoprazole is excreted in the intestine to prevent the destruction of the drug by stomach acids.
Tablets are usually taken with or without food once or twice a day.
Swallow the tablets whole. Do not split, chew or crush them.
Packets of sustained release granules for the oral suspension should be mixed with apple juice and taken through the mouth or fed through a delivery tube.
Oral suspension is usually taken 30 minutes before meals once or twice a day.
Overdose of Pantoprazole
Data on the effect of an overdose of pantoprazole in humans is limited.
Symptoms of overdose in studies of pantoprazole in rats, mice and dogs included:
If you suspect an overdose, you should seek emergency medical help.
The missed dose of Pantoprazole
If you miss a dose of Pantoprazole, take it as soon as you remember.
You should skip it if it’s time for the next scheduled dose.
Do not take an extra dose of this medication.