Perindopril is the general form of Aceon’s proprietary drug, which is used to treat high blood pressure.
Reducing blood pressure can reduce the risk of a heart attack, stroke or other cardiovascular complications.
Perindopril is also used to reduce the risk of a heart attack or death in some people with coronary artery disease.
This drug belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. It works by helping to relax the blood vessels.
The US Food and Drug Administration (FDA) approved perindopril in 1993.
Before taking perindopril, tell your doctor if you have or have ever had:
- Heart disease, heart attack or other heart problem
- Liver disease
- Kidney disease or kidney transplant
- Scleroderma (skin condition)
- Rheumatoid arthritis
- Angioedema (swelling of the face, lips, tongue, throat, hands or feet)
- Allergy to medicines (especially ACE inhibitors)
Also tell your doctor if you have diabetes and are taking medicine Tekturna or Amturnide (aliskiren).
Perindopril can affect blood sugar levels if you have diabetes. Be sure to carefully monitor your status.
Your doctor can recommend a diet and exercise plan for using perindopril. You may also be asked to drink more fluids. Follow these instructions carefully.
Do not take potassium or salt substitutes with perindopril unless your health care provider tells you so.
Excessive sweating, vomiting, diarrhea, or dehydration may increase the risk of developing low blood pressure. Tell your doctor if you experience any of these conditions.
Take care when training and in hot weather.
Let your health care provider know that you are taking this medicine before performing any surgery, including dental procedures.
Pregnancy and perindopril
Perindopril can lead to injury or death of the fetus, if taken during pregnancy.
Immediately notify your doctor if you become pregnant while using this medication.
Use effective contraception to prevent pregnancy with perindopril.
It is not known whether perindopril is ingested in breast milk and whether it can harm a child. Do not breast-feed while using this medication.
Perindopril: side effects
Tell your doctor if any of the following side effects become serious or persistent:
- Light Dizziness
- Easy diarrhea
- Pain in the arm or leg
- Dry cough
- Easy indigestion
- Runny nose
Serious side effects
Immediately notify your doctor if you experience any of the symptoms listed above or any of the following serious side effects:
- Slight dizziness, fainting or severe dizziness
- Changing vision
- Swelling of the hands, ankles, feet or feet
- Symptoms of infection that may include fever, sore throat, or chills
- Abdominal pain
- Yellowing of the skin or eyes (jaundice)
- Urine of dark color
- Pale stools
- Loss of appetite
- Muscle pain, weakness, or spasms
- Weakness on one side of the body
- Red, swollen or flaky skin
- Inconsistent Breath
- Slurred speech
- Decreased or difficult urination
- Fast, slow or irregular heartbeat
- Sudden, severe headache
- Symptoms of anaphylaxis, severe allergic reaction (may include itching, urticaria, difficulty swallowing or breathing, wheezing, chest tightness, or swelling of the mouth, face, lips, tongue, or throat)
Tell your doctor about all the medicines that you take, especially those listed in the “Warnings” section above, and any of the following:
- Gengraf, Neoral or Sandimmune (cyclosporine)
- Lithobide (lithium)
- Non-steroidal anti-inflammatory drugs (NSAIDS) such as Advil or Motrin (ibuprofen) and indocin (indomethacin)
- Insulin and other cures for diabetes
- Injections from arthritis
- Non-prescription drugs containing stimulants (may include diet pills)
Perindopril and other interactions
Perindopril may cause dizziness or fainting.
Use caution when driving, operating a machine, or performing other tasks that require vigilance.
Perindopril and alcohol
Alcohol may increase the risk of certain side effects of perindopril.
Do not drink alcohol when taking this medication before talking to your doctor.
Dosage of Perindopril
Perindopril is supplied in the form of a tablet, which must be taken through the mouth, usually once or twice a day. Your dose will depend on your state of health, the response to the treatment and other factors.
Your doctor can start with a low dose of perindopril and gradually increase it.
Follow the instructions on the label carefully. Do not take more or less perindopril than recommended.
Try to take this medicine at about the same time every day.
Continue to take perindopril, even if you feel good. Do not stop using this medicine without first talking to your doctor.
Symptoms of perindopril overdose may include:
- Severe dizziness
If you suspect an overdose, immediately contact a poison control center or an emergency room.
The missed dose of Perindopril
If you miss a dose of perindopril, take it as soon as you remember.
But if it’s time for the next scheduled dose, skip it and continue with your usual schedule of taking medications. Do not double the dose to make up the missed one.