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Tretinoin is a cure for cancer that inhibits the growth of cancer cells and slows their growth and spread in the body.
Tretinoin is used to treat acute promyelocytic leukemia (such as blood cancer).
Tretinoin may also be used for other purposes not listed in this manual.
Do not use it if you are pregnant. You may need to take a pregnancy test every month during treatment.
You should not use this medicine if you are allergic to Tretinoin or other retinoids (such as Accutane, Retin-A, Renova).
This medicine can cause birth defects, miscarriage, premature birth or death of the child. Do not use tretinoin if you are pregnant. Immediately notify your doctor if you become pregnant during treatment. You may need to get a negative pregnancy test before starting treatment.
Tretinoin can make some birth control pills less effective. Ask your doctor about the best method of birth control to prevent pregnancy with taking Tretinoin.
To make sure that Tretinoin is safe for you, tell your doctor if you have:

  • high cholesterol;
  • liver disease; or
  • a history of a blood clot or a stroke.

It is not known whether Tretinoin passes into breast milk and whether it can harm a feeding baby. You should not breast-feed while using this medication.

Tretinoin: side effects

Obtain immediate medical attention if you have signs of an allergic reaction: shortness of breath; swelling of the face, lips, tongue, or throat.
Call your doctor right away if you have:

  • frivolous feeling, how could you die;
  • ulcers of the mouth and throat, red or swollen gums, burning in the mouth, difficulty swallowing;
  • increased pressure inside the skull – severe headaches, ringing in the ears, dizziness, nausea, vision problems, pain behind the eyes;
  • kidney problems;
  • liver problems – stomach pain, loss of appetite, dark urine, clayey stool, jaundice (yellowing of the skin or eyes);
  • problems with the lungs – pain in breathing, rapid heart rate, lack of breath (especially when lying down);
  • signs of a blood clot – sudden numbness or weakness (especially on one side of the body), speech or balance problems, chest pain, coughing up blood, pain or heat in one or both legs;
  • signs of infection – fever, chills, flu symptoms, slight bruising or bleeding, a new or worsening cough, wheezing, rapid and shallow breathing; or
  • signs of gastric bleeding.

Common side effects may include:

  • fever, weakness, fatigue;
  • nausea, vomiting;
  • pain in the bones;
  • rash, itching, dry skin, increased sweating;
  • hair loss or skin changes;
  • dry mouth, nose, or throat;
  • headache; or
  • changes in vision.

This is not a complete list of side effects, and others may also occur. Tell your doctor about any unusual or annoying side effect.

Tretinoin: interactions

Do not use vitamin A supplements or multivitamins containing vitamin A while you are taking Tretinoin.

This medicine may worsen your thinking or reaction. Be careful if you are driving or doing something that requires attention from you.

This medicine can pass in body fluids (urine, feces, vomiting). Carers should wear rubber gloves. Wash hands before and after removing gloves. Wash contaminated clothing and bedding separately from the other.
Tell your doctor about all the medicines that you use, and what you start or stop using during treatment with Tretinoin, especially:

  • antibiotic – doxycycline, demeclocycline, minocycline, tetracycline.

This list is not complete. Other drugs may interact with Tretinoin, including prescription and over-the-counter medications, vitamins and plant products. Not all possible interactions are listed in this medication guide.

Dosage Tertina

Your doctor will do a blood test to make sure that you have a type of leukemia under which this medication is used for treatment.
Follow all directions on the recipe label. Do not take this medicine in large or small quantities, or longer than recommended.
Take each dose with a full glass of water.
You may need to continue to take Tretinoindustry for up to 90 days. Follow the instructions of your doctor.
Store Tretinoin at room temperature away from moisture, heat and light.
Read all patient information, drug guides and instructions provided to you. If you have any questions, ask your doctor or pharmacist.
Symptoms of overdose may include headache, dizziness, weakness, redness on the face, stomach pains and dry or cracked lips.
Take the missed dose as soon as you remember. Leave it if it’s time for the next scheduled dose. Do not take additional medication to make up for the missed dose.

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